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Saying today was a "difficult day of shared pain," Jim Irsay, the owner of the Indianapolis Colts, said the team was releasing quarterback Peyton Manning from his contract. Manning has been the centerpiece of the Colts' organization for 14 seasons.

Marilyn Tavenner is the acting administrator of the Centers for Medicare and Medicaid Services. Matt, assistant administrator at Jackson Purchase Medical Center in Mayfield, Ky., is her son.

Mitt Romney's campaign aides told journalists Wednesday that it all comes down to delegate math and that their candidate has got the numbers on his side while Santorum and Gingrich don't.

Former President Ronald Reagan would surely be pleased to know that many of his legacies remain vital in 2012, from campaign pledges to lower taxes to ketchup's classification as a vegetable. Reagan is also responsible for a lesser-known contribution to American food culture: National Frozen Food Day.

American Airlines sent word to its employees today that it will not “terminate” pensions after all, but will freeze them.Allied Pilots Association…

Seven others were shot when a gunman opened fire at a psychiatric clinic at the University of Pittsburgh Medical Center.

As the city of Detroit struggles to avoid bankruptcy, those who rely on public transit in Motown are already dealing with severe cutbacks in the city's bus system, driven by attempts to address the precarious financial situation.

"People still want independent, rigorous reporting and The New Republic has been a place where that happens," he tells Morning Edition's Steve Inskeep. He sees a way to connect long-form journalism to the digital age, thanks to tablets.

A year ago Sunday the world shuddered as an earthquake and tsunami destroyed villages and lives in Japan. In the aftermath some 100,000 children were…

Alabama and Mississippi are holding Republican primaries on Tuesday. The contests are vitally important for the candidacies of Newt Gingrich and Rick Santorum. Mitt Romney arrived in Mississippi Thursday night for a rally, and he has a pair of events in Mississippi and Alabama Friday.